Enclomiphene is a selective estrogen receptor modulator (SERM) that is investigated for the treatment of secondary hypogonadism in men. Unlike direct testosterone replacement, enclomiphene works by influencing the hypothalamic-pituitary-gonadal (HPG) axis to boost natural testosterone synthesis. This approach can be particularly beneficial for men wishing to maintain or enhance fertility, as it does not suppress the body's own hormonal signaling in the same way exogenous testosterone can. It is valued for its ability to raise testosterone levels while potentially avoiding some side effects associated with direct testosterone administration.

Enclomiphene citrate acts as an estrogen receptor antagonist at the level of the hypothalamus and pituitary gland. By blocking estrogen's negative feedback on these glands, it leads to an increase in the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Elevated LH levels then stimulate the Leydig cells in the testes to produce more testosterone. FSH plays a role in spermatogenesis, which is why enclomiphene may be more favorable for fertility.

Enclomiphene is administered orally, typically as a daily dose. The specific dosage will be determined by your Genesis Health Solutions provider based on your hormone levels and clinical response. Common side effects can include headache, nausea, dizziness, or visual disturbances, although visual issues are reported less frequently with enclomiphene than with clomiphene citrate (which contains both enclomiphene and zuclomiphene isomers). It's important to discuss your full medical history, including any eye conditions, with your provider. Regular monitoring of hormone levels and potential side effects is necessary during treatment. Enclomiphene may not be suitable for individuals with certain pre-existing conditions, and a thorough evaluation is required before starting therapy.