Estradiol cream is a prescription hormone replacement therapy specifically designed to treat the localized symptoms of menopause. As women approach menopause, the body's natural production of estrogen decreases, which can lead to thinning, drying, and inflammation of the vaginal walls. This condition, known as vulvovaginal atrophy, can cause significant discomfort, irritation, and pain. Estradiol cream provides a low dose of estrogen directly to the affected area to alleviate these symptoms effectively.

This medication works by delivering estradiol, a form of estrogen, directly to the cells of the vaginal lining. This localized hormone replacement helps to restore the normal thickness, elasticity, and lubrication of the vaginal tissues. By replenishing estrogen levels in this targeted way, the cream reverses the atrophic changes caused by menopause, which in turn reduces dryness, alleviates pain during intercourse, and can help decrease the risk of related urinary tract infections.

Estradiol cream should be used exactly as directed by your healthcare provider and is for vaginal use only. It is typically applied using a measured applicator, often daily for the first couple of weeks and then reduced to a few times a week for maintenance. Before using this medication, it is essential to discuss your entire medical history with your doctor, especially if you have a history of cancer, blood clots, or liver disease. While this is a localized treatment with less systemic absorption than oral hormones, it's important to be aware of potential side effects, which can include vaginal irritation, breast tenderness, and headaches. Regular check-ups with your doctor are necessary to ensure the treatment remains appropriate for you.